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In DOR, the decline in follicle number reduces estradiol and inhibin B secretion, thereby altering GnRH pulsatility and the LH/FSH ratio, which impairs corpus luteum formation and predisposes to luteal insufficiency [31]

Furthermore, investigations into the combination of CB-839 with immunotherapy have yielded encouraging outcomes, exemplified by its synergistic effect with nivolumab in patients diagnosed with melanoma, clear cell renal cell carcinoma, and NSCLC [217]