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Nair, 2020) and the majority do not benefit from GDMT ( 1.1 Challenges in modeling HFpEF Unlike HFrEF, HF in HFpEF patients usually does not trace back to a primary injury of cardiomyocytes but rather a plethora of extra-cardiac perturbations (Ho et al., 2016), including obesity (Savji et al., 2018), diabetes (Lejeune et al., 2021), aging and hypertension (Packer et al., 2020)

A prospective feasibility trial applying the MAD to patients with glioblastoma who were not receiving chemotherapy reported that four patients were stable or improved after 16 weeks of dietary intervention

[DOI] [PMC free article] [PubMed] [Google Scholar] 34.Prabhakar NR & Semenza GL Regulation of carotid body oxygen sensing by hypoxia-inducible factors