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More recent evidence showed that insomnia patients have lower initial NREM low-frequency power, and that the normal dissipation of low-frequency power across the night is compromised 31

[DOI] [PubMed] [Google Scholar] 258.Zhang RX, Kang R, Tang DL

This data indicates that apoE4 impacts the delicate balance of sirtuin isoforms in the context of neuroprotection and opens innovative strategies for the treatment of AD
