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The response to different ion concns

[DOI] [PubMed] [Google Scholar] 106.Goh SH, Hew NF, Norhanom AW, Yadav M

Likewise, multifunctional nanomedicine platforms designed to induce ferroptosis, such as DHA-loaded Fe 3+ -doped MnO 2 nanosheets, may trigger excessive ROS generation and glutathione depletion beyond the tumor boundary, potentially leading to systemic inflammation, immune dysfunction, and off-target toxicity that could compromise patient safety

Indeed, SOD supplementation may trigger the endogenous antioxidant machinery to neutralize a free radical excess without being consumed upon ROS detoxification