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Moreover, DHODH-mediated ferroptosis is independent of FSP1, as ectopic expression of mitochondria-localized FSP1 is unable to protect cells from ferroptosis [73]

For instance, researchers can use humanized microbiota models to evaluate the impact of specific probiotics or prebiotics on the composition and function of gut microbiota, and subsequently assess their effects on immune responses and tumor growth in the lungs (98)

On the other hand, due to the broad substrate specificity in the -GCS reaction, instead of Cys, any amino acid could serve as the substrate for -glutamylation with varying efficiency

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