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doi: 10.1179/135100003125001378
In contrast, transgenic overexpression of SOCS3 in POMC neurons leads to leptin resistance and obesity [142]
The mechanism involves the sudden spike in growth hormone affecting various systems simultaneously
Importantly, treatment of DIO mice with our NNMT inhibitors did not impact food intake, but produced marked reductions in body weight, WAT mass, adipocyte size, and cholesterol levels with negligible toxicity or observable adverse effects
