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The way it works is fairly well mapped out: Your skin has cells called fibroblasts that build collagen (the stuff that keeps skin firm and smooth)

Deletion of vitamin D receptor leads to premature emphysema/COPD by increased matrix metalloproteinases and lymphoid aggregates formation

doi: 10.1002/mds.26362 111 RayS.SinghN.KumarR.PatelK.PandeyS.DattaD.et al