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Conversely, the ER stress inhibitor (4-PBA) did not mitigate PFOS-phosphorylated ERK1/2 levels at 1 h of PFOS treatment in RTCs, but it reduced the level of LC3BII (an autophagy biomarker) at 24 h of PFOS treatment in RTCs (Fig

Tenofovir Alafenamide (TAF) Based on prospective reports to the APR of over 660 exposures to TAF-containing regimens during pregnancy resulting in live births (including over 520 exposed in the first trimester and over 130 exposed in the second/third trimester), the prevalence of birth defects in live births was 4.2% (95% CI: 2.6% to 6.3%) and 3.0% (95% CI: 0.8% to 7.5%) following first and second/third trimester exposure, respectively, to TAF-containing regimens