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doi: 10.1016/j.biopha.2019.109625 85 ZhuHXYangSHGaoCYBianZHChenXMHuangRRet al

Melanophages play a critical role in what is defined as dermal melanosis or pigmentary incontinence

However, a warning from some research reports and National Authorities raised NSAIDs safety concerns because of the supposed induction of angiotensin-converting enzyme 2 (ACE2) levels (the receptor used by SARS-CoV2 to enter host airways cells), the increased risk of bacterial superinfections and masking of disease symptoms

While conventional therapies have certain limitations, inhalation formulations have emerged as an effective strategy for the treatment of these conditions, owing to their ability to achieve uniform lung distribution, rapid onset of action, high bioavailability, and avoidance of hepatic first-pass metabolism