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Certain pain medicationsparticularly opioidscan increase pain sensitivity over time through a process known as opioid-induced hyperalgesia

The GSH/GPX4 node is the crucial regulator of ferroptosis The GSH system, as a lipid peroxide scavenger, has attracted much attention as a potential therapeutic target for ferroptosis

H.ShinJ.KimJ.-S.ChaB.LeeS.et al
