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While the in vitro model using KRAS-derived PDAC cells had a promising impact, the in vivo experiment, unfortunately, did not achieve reduced cell growth due to the adaptive metabolomic plasticity of those cells in response to CB-839 [43]
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(PDF 148 kb) Glossary Alarmone A stress-induced hormone that switches bacterial cells from a growth state to a survival state
These animals develop age-associated obesity caused by an induction of glycerol kinase and increased storage of TAG (53)
