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A dose administered during the course of the day promotes improved sleep on the subsequent night and for several nights thereafter a temporal profile incompatible with direct sedation and consistent with a neuromodulatory mechanism acting on sleep homeostatic systems

National Academies Press (US).

Chemotherapy combined with sorafenib can effectively reduce serum HIF-1 and VEGF levels in patients with GC to improve their 1-year survival rate and prognosis (116)

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