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Glutathione is the master antioxidant while glutathione levels decline with age in our bodies

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[DOI] [PMC free article] [PubMed] [Google Scholar] 11.Allais G., DAndrea G., Maggio M., Benedotto C

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In addition, ozone therapy exerts a regulatory effect on key transcription factors: it activates Nrf2, endorsing antioxidant and anti-inflammatory responses, while concurrently inhibiting NF-kB, integral in inflammation regulation [18, 33, 35, 36]

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Together, dysregulation of these proteins suggests a mechanism of impaired anti-oxidant/anti-inflammatory activity and increased oxidative stress and inflammation response in the aged hippocampus

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