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Additional dose groups (including higher single-dose ranges) have been discussed in regulatory/nomination documents

Contraindications/Precautions Intravenous administration of Vitamin B preparations should be done slowly and if necessary, the preparation should be diluted to avoid speed reaction

This analysis excluded trials in those with end-stage renal disease, who are at high risk of cardiovascular events and mortality

There is no robust body of randomized controlled trial data demonstrating that lipotropic injections cause clinically significant fat loss beyond what the accompanying calorie restriction, activity changes, and clinical monitoring would have produced anyway