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Upon binding to its ligands on damaged and apoptotic cells, it undergoes a conformational change that allows for binding and activation of C1 and may lead to dissociation to monomeric CRP 18,24,27,28,29,30
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( C F ) qPCR analysis of Nppb , Casp3 , Bax, and Noxa mRNA expression in NMCMs treated with or without the JNK inhibitor SP600125 (10 M) for 30 min followed by transfection with control siRNA or Mc5r targeting siRNA for 24 h
