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To evaluate Dihexas ability to cross the BBB and accumulate in brain regions, rats were fitted with carotid cannulas and infused with a mixture of [H]Dihexa (10 Ci) and [C]inulin (2 Ci), a vascular space marker, in 100 l of isotonic saline

The peptide also tolerates lyophilisation and reconstitution without measurable loss of activity, and stable storage at -20C exceeds 24 months in published shelf-life data

On the other hand, large predatory fish (such as swordfish) tend to concentrate pollutants, particularly persistent organic pollutants, heavy metals, and microplastics, due to biomagnification and bioaccumulation

doi: 10.17113/ftb.60.02.22.7340 137 DenaroR.AulentaF.CrisafiF.Di PippoF.Cruz ViggiC.MatturroB.et al