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DIA files were processed using Spectronaut with default settings, with PTM localization activated and site confidence score cutoff set to 0 (for peptide-level analysis of dilution benchmark), 0.75 (for spectral library analysis) or 0.99 (for direct DIA analysis), data filtering set to Q- value and Normalization Strategy set to Local Normalization

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Neurological and Neurodegenerative Conditions Neurological applications remain highly preliminary based on animal model studies

The present review provides an overview of the fundamental role of copper and its metabolic pathways in physiology