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Possible Side Effects Most people tolerate NAD+ injections well, but some may experience: Mild redness, tenderness, or soreness at the injection site Warmth or flushing Lightheadedness, nausea, or brief fatigue In rare cases, allergic reactions seek immediate care if you experience severe symptoms Tips to reduce discomfort: Inject slowly over 2030 seconds Rotate injection sites to avoid irritation Drug Interactions No major interactions have been reported