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History of B-12 as a treatment for pernicious anemia B-12 deficiency is the cause of pernicious anemia, a usually-fatal disease of unknown etiology when it was first described in medicine

There was a tendency toward higher t 1/2 with increasing hepatic impairment, but applying the same rationale as stated above for participants with renal impairment, this was not considered clinically relevant

[DOI] [PMC free article] [PubMed] [Google Scholar] 84.Malbert C-H, Chauvin A, Horowitz M, et al
