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Studies have shown that microglia originate from embryonic yolk sac progenitors during early development, are of primitive hematopoietic origin, and persist into adulthood, maintaining independence from bone marrow-derived myeloid cells throughout life, shaping their distinct functions across maturation and aging (Ginhoux et al., 2013

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[DOI] [PMC free article] [PubMed] [Google Scholar] 157.Salehi B., Stojanovi-Radi Z., Mateji J., Sharifi-Rad M., Anil Kumar N.V., Martins N., Sharifi-Rad J