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Overproduction of reactive oxygen species occurs when inflammation induces oxidative stress in macrophages and microglia, leading to a self-sustaining cycle of cellular damage and neuroinflammation
PANoptosis is a distinct innate immune-mediated inflammatory lytic cell death pathway initiated by pattern-recognition receptors and propagated via the PANoptosome complex, which plays a critical hub role in the interactive regulation between immunometabolic dysregulation and inflammatory programmed cell death in diabetes
