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Their results showed that TSA pretreatment downregulated histone deacetylase 1 (HDAC1) expression, thereby promoting nuclear translocation of Nrf2 and upregulating antioxidant proteins, including HO-1, cystine transporter xCT and GSH peroxidase 4 (Gpx4)
Cysteine, glutathione and a new genetic code: Biochemical adaptations of the primordial cells that spread into open water and survived biospheric oxygenation
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