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We have not experimented too much with such engineered losses, but we believe they can make training more efficient, even though such engineering methods deviates from the end-to-end training paradigm,

In the early stage of alveolar injury, neutrophils are recruited into the injured sites, triggering an immune response by releasing pro-inflammatory cytokines and producing neutrophil elastase (NE) to exacerbate fibrosis (Figure 1)
& Blanco-Bercial, L
