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This combination appeals to patients pursuing metabolic optimization, though clinical evidence for the synergistic benefit of inositol and choline alongside B12 remains limited

Its best to get vitamin B12, and all other nutrients, from all-natural food sources whenever feasible
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Cancer Cell 18:207219 Wang D, Meng G, Zheng M et al (2016) The glutaminase-1 inhibitor 968 enhances dihydroartemisinin-mediated antitumor efficacy in hepatocellular carcinoma cells