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Acute or prolonged oral administration of pyritinol reduced formaldehyde-induced nociceptive behavior and tactile allodynia in old diabetic rats

However, it requires full detoxification prior to initiation, which can be a barrier for many patients

Ewes require additional B12 to support high glucose demands for lamb growth in utero and lactation

however, in metabolically healthy populations, evidence of a direct fertility effect is lacking
