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Orotidylate carboxylase, encoded by URA3, is an enzyme that is necessary for the de novo biosynthesis of pyrimidines converting orotidine-5-P to UMP (Fig 13) [215]

This indicates federal authorities found credible evidence that: False or misleading claims were made to secure federal funding Those claims were grounded in the retracted, fabricated Benoist study The company's entire development strategy was influenced by fraudulent data This is not merely a matter of one bad paperit suggests deeper issues in the scientific and corporate oversight of this compound's development

Kosinski-Collins, M

The FDA isnt deciding whether these compounds are safe