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However, some individuals report experiences that suggest possible associations between B12 and anxiety-like symptoms in certain contexts: High-dose supplementation : Some individuals report feeling 'overstimulated' or experiencing changes in energy levels when initiating B12 supplements

Anti-ubiquitinated myeloperoxidase antibodies in SLE sera enhance cytokine production by macrophages upon NET stimulation, suggesting a role for extracellular ubiquitin in lupus-related inflammation

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