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4A), indicating that the RNase activity of IRE1 is responsible for this regulation

[DOI] [PMC free article] [PubMed] [Google Scholar] 209.Valds-Ramos R., Guadarrama-Lpez A.L., Martnez-Carrillo B.E., Bentez-Arciniega A.D

elegans To test whether HSF-1 induces the expression of UPR ER genes upon heat shock, we compared two sets of HSF-1 regulated genes 19,20 with a published gene set containing differentially expressed genes (DEGs) that were upregulated by tunicamycin-induced ER stress, and this was dependent on the activity of UPR ER regulators ATF-6, IRE-1 or PEK-1 21

However, the full scope of its efficacy and safety is still under investigation