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In the olfactory nerve pathway, therapeutic agents absorbed from the olfactory epithelium diffuse through the CSF surrounding the brain via perineural channels

Progressive nigrostriatal terminal dysfunction and degeneration in the engrailed1 heterozygous mouse model of Parkinson's disease

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Patients present with viral infections, atopic eczema, impaired T-cell function and TH17 cell differentiation, with defective eosinophil homeostasis and dysregulation of IgE (42, 43)
