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Diabetic hyperglycemia triggers paradoxical glycolysis suppression despite energy deficits, while microglial advanced glycation end products (RAGE) receptors, a dual insult exacerbating acidosis and neuroinflammation, are evidenced by diabetics exhibiting 3 higher lactate/penumbra volume ratios than non-diabetics [46, 129]

He finished first in three straight New York City Marathons in the early 1980s, at one point held national records for both the 5K and the 10K on the track, and for decades had a successful second act as a coach, helming Nikes famed Oregon Project

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