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Argente J, Caballo N, Barrios V, Munoz MT, Pozo J, Chowen JA, Morande G, Hernandez M 1997 Multiple endocrine abnormalities of the growth hormone and insulin-like growth factor axis in prepubertal children with exogenous obesity: effect of short- and long-term weight reduction

Cellular senescence and regulated cell death of tubular epithelial cells in diabetic kidney disease

Retention of oxidized glutathione by isolated rat liver mitochondria during hydroperoxide treatment

An accumulation of TCA intermediates may subsequently have an impact on the macrophage phenotype, e.g., by contributing to a pro-inflammatory phenotype [e.g., as shown for succinate (Tannahill et al., 2013) and oxaloacetate (Infantino et al., 2011)] or by triggering innate immune memory [for fumarate ( 4.2.1 TCA intermediate accumulation in M1 and trained macrophages More specifically, increased glutamine uptake in LPS-stimulated macrophages triggered the accumulation of succinate, which stabilized HIF1 and thereby increased the expression of the inflammatory mediator IL-1 (Tannahill et al., 2013)